The Vibrant Wellness Advantage

The Vibrant Wellness Advantage Simple testing with robust results. Perform the Food Sensitivity tests in the comfort of your home, or work with your provider to find a convenient testing center. Our proprietary technology detects: Food Sensitivity with 95%-100% accuracy IgA and IgG antibodies Sensitivity to 209 different foods Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

What are the Food Sensitivity Tests?

Vibrant’s Food Sensitivity Tests are blood panels that detect sensitivities to up to 209 different foods depending on the panel ordered. The panels assess immune response to whole, raw, water-soluble proteins that are commonly consumed to determine an individual’s risk for negative food reactions. There are three panel options for The Food Sensitivity Test: Food Sensitivity Profile 1 (96 foods) Food Sensitivity Profile 2 (84 foods) And Food Sensitivity Complete (209 foods) Each panel also comes in two antibody type options: IgA and IgG or IgG4 and C3d. Both antibody options can be combined to gain a full assessment of food sensitivity by measuring IgA, IgG, IgG4 antibodies and C3d together.

What are Food Sensitivities?

Food sensitivities are immune-mediated, non-allergenic reactions to food protein antigens, in which antigens bind to antibodies and form an antigen-antibody immune complex. This process can also evoke systemic immune responses. Symptoms of food sensitivities are often delayed and hard to pinpoint or detect. It’s important to note that food intolerances differ from food sensitivities because they do not involve the immune system— rather, they result from a deficiency in proteins or enzymes critical to proper digestion of a food (i.e., lactose intolerance). Food sensitivities are also referred to as loss of oral tolerance, which is what happens when the intestinal immune system forms immune-based reactions to commonly consumed and typically harmless foods or antigens.

Which Patients Benefit from This Test?

Conditions and symptoms which may benefit from food sensitivity testing include:

History of food sensitivities, Gastrointestinal dysfunction, Diarrhea, Constipation, IBS Neurological disorders, Autoimmune diseases, Inflammatory conditions, Skin manifestations, Eczema, Headaches/migraines, Joint pain, Asthma, Cognitive impairments, Brain fog, Fatigue.

Food Sensitivity Markers List

Beta-Casein Casomorphin Cow’s Milk Goat’s Milk Whey Protein Buffalo milk Buttermilk Cheese cheddar Kefir Sheep’s milk Yoghurt Fish Catfish Codfish Halibut Lake Trout Mackerel Perch Salmon Tuna Alaska pollock Anchovy Carp Eel Flounder Sardine Sea bass Sole Meat Beef Chicken Egg white Egg yolk Lamb Pork Turkey Duck meat Goose meat Grapevine snail Rabbit Veal Shellfish Crab Lobster Shrimp Crayfish Clam Oyster Scallops Blue mussel Octopus Pacific squid Squid Legumes Kidney Bean Navy Bean Peanuts Soybean Chickpea Broad bean Mung beans Black Beans Black-eye Peas Lentils Pinto Beans Spices Black Pepper Cinnamon Nutmeg Anise Bay leaf Caraway Cayenne pepper Common thyme Curry powder Dill Hot paprika powder Oregano Parsley Woo-hsiang powder Cumin Cilantro Habanero pepper Jalapeno pepper Turmeric Gluten containing grains Barley Wheat Malt Oats Rye Wheat Spelt Cous cous Amaranth Brown Rice Buckwheat Corn Millet Arrowroot Cassava Tapioca Tiger nut Taro Root Cocoa Coffee Hops Rosemary Vanilla Bean Yeast Black tea Cane sugar Lemon grass Molasses Oolong tea Agave Espresso Green Tea Nuts Almond Black Walnut Cashews English Pecan Hazelnut Pine nut Pistachio nut Sweet chestnut Brazil nut Macadamia Nut Green Pepper White Potato Eggplant Seeds Mustard Sesame Coriander seed Flaxseed Poppy seed Rape seed Sunflower seed Chia Hemp Apple Apricot Avocado Banana Blackberry Blueberry Cantaloupe Cherry Coconut Cranberry Grape Grapefruit Lemon Olive Orange Peach Pear Pineapple Raspberry Strawberry Tomato Watermelon Fig Guava Honeydew melon Kiwi fruit Litchi Mandarin Mango Plum Capers Papaya Arrowroot Cassava Tapioca Tiger nut Taro Root Broccoli Cabbage Carrot Cauliflower Celery Cucumber Garlic Green Bean Green Peas Lettuce Lima Bean Mushrooms Onion Seaweed (Kelp) Spinach Squash Ginger Sweet Potato Asparagus Bamboo shoots Beet root Endive Leek Roquette Savoy cabbage Turnip Vine leaf White radish Artichoke Chard Kale Shiitake mushroom Zucchini Acorn Squash Butternut Squash Green onion/Scallions Parsnip Portabella Mushroom Purple Potato Shallots Spaghetti Squash Tofu Tempeh Vegan Cheese

The Vibrant Wellness Advantage

Two different blood-based antibodies to differentiate between IBS and IBD. Anti-CdtB antibodies (to detect past cases of food poisoning) Vinculin antibodies (to rule out the presence of IBD) Antibodies to 10 common fungal antigen common fungal antigenss Simple testing with robust results. Perform the Candida + IBS Profile panel in the comfort of your home. Unparalleled specificity and sensitivity. Our proprietary technology detects: Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

Who Will Benefit from Candida + IBS Profile testing?

The Candida + IBS Profile assesses the presence of Candida (fungal) overgrowth, antibody levels associated with Irritable Bowel Syndrome (IBS), and autoimmune-related alterations in intestinal motility. You may benefit from this panel if you’ve been diagnosed with or suspect intestinal permeability, exposure to mold or other fungi, autoimmune disease, or chronic inflammation. Recognizing Symptoms of IBS and Bacterial/Fungal Overgrowth

Why is This Test Important?

IBS is the most common gastrointestinal disorder, with worldwide prevalence rates ranging from 10-15%. Candida is a fungal pathogen that is healthy in normal amounts, but if allowed to overgrow, it can wreak havoc on the digestive system and create an imbalanced gut microbiome. Candida overgrowth can also cause infections in the bloodstream or major organs; Candidemia is one of the most common bloodstream infections in the US. Fungal or bacterial overgrowth and infections can cause increased intestinal permeability, leading to chronic inflammation and conditions such as IBS. The Vibrant Wellness Candida + IBS Profile helps identify IBS-diarrhea predominant (IBS-D) or IBS-mixed type (IBS-M) associated with fungal/bacterial overgrowth and determine if pathogens are at the root of your digestive symptoms. The panel will allow you to discover the source of your symptoms and build a personalized wellness plan with your provider to address inflammation, resolve fungal or bacterial overgrowth, and improve your lifestyle.

Candida + IBS Profile Markers List

Candida albicans Candida dubliniensis Candida glabrata Candida guilliermondii Candida krusei Candida lusitaniae Candida parapsilosis Candida tropicalis Cladosporium Saccharomyces cerevisiae Trichosporon ovoides Cytolethal distending toxin B Vinculin

What is the Gut Zoomer?

The Gut Zoomer is a stool test that measures over 170 species of bacteria and gut pathogens along with markers of inflammation, digestion, and gut metabolites.

Why Order This Test?

The Gut Zoomer provides a comprehensive gut overview, including insight on common gut imbalances such as loss of beneficial organisms, excessive growth of potentially harmful organisms, and loss of overall microbial diversity. Knowing the abundance of bacteria in your patient’s gastrointestinal tract is important because gut microbiota impacts several critical aspects of health, including: Shaping the immune system Fortifying the intestinal mucosal barrier Influencing nutrient metabolism Vibrant’s Gut Zoomer aids practitioners in detecting root causes of acute or chronic illness that stem from the gastrointestinal tract—including gastrointestinal disorders like Crohn’s disease, autoimmune conditions like Hashimoto’s thyroiditis and rheumatoid arthritis, and extraintestinal conditions like atherosclerosis, diabetes, eczema, and psoriasis.

Which Patients Benefit From This Test?

Conditions, signs, and risks associated with gut dysbiosis include:

GERD Gas and bloating Indigestion Liver and gallbladder disease Small intestinal bacterial overgrowth (SIBO) Malnutrition Nutrient deficiencies Fatigue Food sensitivities Intestinal permeability (‘leaky gut syndrome’) Diabetes Skin rashes (eczema or dermatitis) Inflammatory symptoms Infections Autoimmune conditions Celiac disease Inflammatory bowel disease (Crohn’s, ulcerative colitis) Irritable bowel syndrome (IBS) Cardiovascular disease Metabolic syndrome Neurological disorders Mood abnormalities

Gut Zoomer Test Markers

Vibrant’s Gut Zoomer includes three sections: gut commensal microbes, gut digestive markers, and gut pathogens.

The Gut Zoomer also highlights low levels of probiotic organisms to guide personalized probiotic recommendations.

Gut Commensal Microbes: Proteobacteria (e.g., Enterobacteriaceae, Escherichia coli, Proteus mirabilis) Actinobacteria (e.g., Bifidobacterium, Micrococcus, Eggerthella lenta) Firmicutes (e.g., Clostridum, Streptococcus, Staphylococcus, Feacalibacterium, Roseburia) Bacteroidetes (e.g., Prevotella copri, Bacteroides vulgatus, Prophyromous gingivalis) Verrucomicrobia (e.g., Akkermansia muciniphila) Euryarchaeota (e.g., Methanobrevibacter smithii)

Gut Pathogens: 22 Bacteria 13 Protozoans 15 Helminths 11 Viruses 5 Fungi 6 Antibiotic Resistance Genes

Gut Metabolites: Bile acids Short-chain fatty acids

Gut Digestive: Diversity Indexes, Phyla Overview, Key Ratios Inflammatory Markers Calprotectin Fecal lactoferrin Beta defensin Fecal eosinophil protein X Markers of Digestive Insufficiency and Malabsorption Pancreatic elastase-1 Meat and vegetable fibers Fecal fats

Other Markers: Secretory IgA Fecal occult blood PH Beta-glucuronidase Fecal zonulin Fecal anti-gliadin

The Vibrant Wellness Advantage

Simple testing with robust results. Perform the Whole Blood Nutrient Panel in the comfort of your home Unparalleled specificity and sensitivity. Our proprietary technology detects: Direct levels of short-term micronutrients, including vitamins, minerals, co-factors, amino acids, metabolites, and antioxidants Levels of nutrients in circulating white and red blood cells Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

Who Will Benefit from Whole Blood Nutrient Profile?

The Whole Blood Nutrient Profile measures the nutrient status of common vitamins, minerals, antioxidants, metabolites, and amino acids, providing a baseline assessment of your whole blood micronutrient status. If you are diagnosed with or suspect you have a chronic inflammatory condition, autoimmune disease (Celiac, Crohn’s, etc.), or any condition associated with nutrient malabsorption, you may benefit from this panel.

Recognizing Symptoms of Micronutrient Deficiency Symptoms include:

Stress Fatigue Depression or anxiety Skin problems Numbness or tingling in extremities Weakened immune system Lack of concentration/brain fog Fluctuating weight Neurological symptoms (impaired memory, confusion, ataxia, loss of balance, tremors) Stubborn weight gain Sudden, unexplained weight loss Digestive abnormalities: diarrhea, constipation, excessive bloating.

Why is This Test Important?

High-calorie, low-nutrient foods comprise an estimated 27% of daily caloric intake in the typical American diet Micronutrients play a vital role in energy production, hemoglobin synthesis, maintenance of bone health, adequate immune function, and protection of the body against oxidative stress and cellular damage Micronutrient deficiencies can be a sign of chronic inflammation Chronic inflammation is associated with several chronic diseases, including heart disease, diabetes, cancer, arthritis, Crohn’s disease, and ulcerative colitis Uncovering micronutrient deficiencies is an easy and critical step in addressing chronic conditions and healing.

Whole Blood Nutrient Profile Markers:

Vitamin A Vitamin C Vitamin B1 Vitamin D3 Vitamin B2 Vitamin E Vitamin B3 Vitamin K1 Vitamin B5 Vitamin K2 Vitamin B6 Folate Minerals Calcium Iron Chromium Magnesium Copper Manganese Copper to Zinc Ratio Zinc Amino Acids Arginine Isoleucine Asparagine Leucine Citrulline Serine Glutamine Valine Antioxidants Coenzyme Q10 Glutathione Cysteine Selenium Metabolites Carnitine Inositol Choline Methylmalonic acid (MMA) Omega Fatty Acids (Optional Add-On) Docosahexaenoic acid (DHA) Linoleic acid (LA) Eicosapentaenoic acid (EPA) Arachidonic acid (AA) Docosapentaenoic acid (DPA) Total Omega 6% Total Omega 3% AA/EPA Ratio Omega 3 Index Omega 3/Omega 6 Ratio

The Vibrant Wellness Advantage

Simple testing with robust results. Perform the Organic Acids Test in the comfort of your home. Unparalleled specificity and sensitivity. Our proprietary technology utilizes 11 different subpanels to detect: intestinal microbial overgrowth indicators of detoxification mitochondrial markers neurotransmitter metabolism markers Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts. glutathione status fatty acid metabolism markers inborn errors of metabolism micronutrient deficiencies.

What is The Organic Acids Test?

Vibrant’s Organic Acids Test is a urine-based test that measures organic acid excretion in a single urine collection sample first thing in the morning. Vibrant’s Organic Acids test includes 78 metabolic markers that can accurately identify conditions associated with genetic disorders, nutrient deficiencies, intestinal dysbiosis, and toxicity from the diet, environment, and certain medications.

Who Will Benefit from the Organic Acids Test?

The Organic Acids Test detects the organic acids in urine that are byproducts of daily cellular metabolism. The panel can accurately identify conditions associated with genetic disorders, nutrient deficiencies, intestinal dysbiosis, and toxicity from diet and prescription drugs. The Organic Acids panel is designed to take a broad look at multiple systems and get a snapshot of how the body is functioning.

Conditions and Symptoms that may benefit from an Organic Acids Test:

ADD/ADHD Autism spectrum disorder Mental and/or developmental delays Difficulty concentrating Hyperactivity Chronic fatigue syndrome Fibromyalgia Fatigue and weakness Depression and/or anxiety Confusion or dizziness Mood disorders or mood swings Insomnia or other sleep problems Slowed reaction time Poor memory Headaches or migraines Digestive dysfunction Nausea or vomiting Poor appetite Abdominal pain, diarrhea, bloating Hypo- or hyperglycemia Unexplained weight gain/loss Muscle weakness Hypotonia Chronic pain Eczema or dermatitis Immune deficiency or frequent infections Anemia Hearing, speech, or visual impairment Tachycardia Rapid or abnormal breathing Kidney stones Seizure disorders Other neurological disorders

Organic Acids Test Markers:

Yeast and Fungal Markers

Citramalic Acid 5-Hydroxymethyl-furoic Acid 3-Oxoglutaric Acid Furan-2,5-dicarboxylic Acid Furancarbonylglycine Tartaric Acid Arabinose Carboxycitric Acid Tricarballylic Acid

Bacterial Markers

Hippuric Acid 2-Hydroxyphenylacetic Acid 4-Hydroxybenzoic Acid 4-Hydroxyhippuric Acid DHPPA

Clostridia Bacterial Markers

4-Hydroxyphenylacetic Acid HPHPA 4-Cresol Indoleacetic Acid

Detoxification & Oxidative Stress Markers:

Pyroglutamic Acid 2-Hydroxybutyric Acid N-acetylcysteine Acid Orotic Acid Mandelic Acid

Energy Metabolism & Mitochondrial Function Markers

Succinic Acid Fumaric Acid Malic Acid 2-Oxoglutaric Acid Cis-aconitic Acid Citric Acid Lactic Acid Pyruvic Acid 3-Hydroxybutyric Acid Acetoacetic Acid 4-Hydroxybutyric Acid Adipic Acid Suberic Acid Sebacic Acid Ethylmalonic Acid Methylsuccinic Acid 3-Methylglutaric Acid 3-Methylglutaconic Acid 3-Hydroxyglutaric Acid

Amino Acid Metabolites

2-Hydroxyisovaleric Acid 3-Methyl-2-oxovaleric Acid 2-Hydroxyisocaproic Acid 2-Oxoisocaproic Acid 2-Oxo-4-methiolbutyric Acid Phenyllactic Acid Phenylpyruvic Acid Homogentisic Acid 4-Hydroxyphenyllactic Acid N-Acetylaspartic Acid Malonic Acid 2-oxoisovaleric Acid

Nutrition & Oxalate Markers

3-Hydroxybutyric Acid Acetoacetic Acid 4-Hydroxybutyric Acid Adipic Acid Suberic Acid Sebacic Acid Ethylmalonic Acid Methylsuccinic Acid 3-Hydroxy-3-methylglutaric Acid

Catecholamine Metabolites & Ratios

HVA/VMA Ratio HVA/DOPAC Ratio DOPAC HVA VMA

Serotonin Metabolites & Ratios

Quinolinic Acid Quinolinic Acid/ 5-HIAA Ratio 5-HIAA Kynurenic Acid

The Vibrant Wellness Advantage

Unparalleled specificity and sensitivity. Our proprietary technology detects IgG, IgA, and IgM antibodies to common viral infections. Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts. About Vibrant Wellness Vibrant Wellness is a leading CLIA-certified and CAP-accredited biotech company based in Santa Clara, CA. We deliver life-transforming lab testing that enables health and wellness providers to discover the root of patient health issues. We’re at the forefront of modern medicine and research, providing personalized health analytics using cutting-edge, high-quality technology. We believe that anyone can achieve better health and vibrant longevity through individualized solutions based on testing—not guessing.

What is the Viral Infections Panel?

Vibrant’s Viral Infections Panel is a blood test that detects IgG and IgM antibodies to six viruses and one bacterium that can be ordered as a blood draw or at-home dried blood spot test. The Virus Infection Panel assesses antibody responses to infections that are commonly associated with numerous health conditions. This is a stand-alone test for infections.

Which Patients Benefit From This Test?

Conditions and symptoms which may benefit from testing infections include:

Neurological disorders Autoimmune diseases Inflammatory conditions Gastrointestinal dysfunction Immune dysfunction Cancer Chronic fatigue syndrome Fibromyalgia Chronic pain Joint pain Chronic illness Headaches/migraines Cognitive impairments Brain fog ADHD Autism spectrum disorder PANS/PANDAS Behavioral issues Multiple sclerosis

Key Markers:

Cytomegalovirus EIA Antigen HSV-1 Cytomegalovirus GlyB HSV-2 Cytomegalovirus p150 Human Herpesvirus Cytomegalovirus p28 HHV-6 Cytomegalovirus p52 HHV-7 Cytomegalovirus p65 Streptococcal A Cytomegalovirus p38 Streptococcal A Epstein Barr Virus EA Antigen Epstein Barr Virus EBNA1 Epstein Barr Virus VCA gp125 Epstein Barr Virus p18 Epstein Barr Virus p23

The Vibrant Wellness Advantage

29 of the most common mycotoxins produced by mold Molecules at the parts per quadrillion size Simple testing with robust results. Perform the Mycotoxins panel in the comfort of your home. Unparalleled specificity and sensitivity. Our proprietary technology detects: Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

Recognizing Symptoms of Mycotoxin Toxicity

Shortness of breath Anxiety (fears, uneasiness) Red or swollen eyes Itchy eyes Sensitivity to light Irregular heartbeat Stiff muscles Insomnia at night Lack of concentration/brain fog Increased urinary frequency Swelling/burning lips/tongue Wheezing Depression Rashes or hives Watery eyes Headache Stiff joints Daytime sleepiness Forgetfulness Itchy skin

Why Is This Test Important?

According to the World Health Organization and Food and Agricultural Organization, 25% of the world’s agricultural products are contaminated with mycotoxins. People with mold exposure can present with conditions and symptoms affecting multiple organs and systems within the body, including respiratory system (sinus and lungs), musculoskeletal system (muscles, bones, and connective tissues), and the central and peripheral nervous systems (brain, spine, and nerves). Symptoms of mycotoxin toxicity are often general and vague, and thus difficult to diagnose, leaving you at risk of long term health damage. The Vibrant Wellness Mycotoxins panel provides the most comprehensive view of mycotoxin levels and exposure so you and your provider can create personalized wellness plans to prevent and resolve mycotoxin toxicity..

Mycotoxin Test Key Markers:

5 Aflatoxins: Aflatoxin B1 Aflatoxin G2 Aflatoxin B2 Aflatoxin M1 Aflatoxin G1

13 Other Mycotoxins: Chaetoglobosin A Citrinin Dihydrocitrinone Enniatin B1 Fumonisins B1 Fumonisins B2 Fumonisins B3 Gliotoxin Mycophenolic Acid Ochratoxin A Patulin Sterigmatocystin Zearalenone

11 Trichothecenes: Deoxynivalenol Diacetoxyscirpenol Nivalenol Roridin A Roridin E Roridin L2 Satratoxin G Satratoxin H T-2 Toxin Verrucarin A Verrucarin J

What is The Environmental Toxins Test?

Vibrant’s Environmental Toxins test measures urinary excretion of environmental toxins, providing insight into environmental toxin exposure. Environmental toxins are ubiquitous. In 1994, the US released over 2 billion pounds of environmental toxins, which grew to nearly 5 billion pounds in 2002¹. While the US released 3 billion pounds of chemicals in 2020, this represents a 27% decrease since 2011.² The decrease is attributed to 34% reduction in air pollution from 2011 to 2020, driven by reduced air emissions from electric utilities.² The EPA inventory contains roughly 84,000 chemical substances that are in commerce, many of which have limited testing for their effects on humans or the environment³. Chemicals no longer authorized for use in the U.S. (e.g., DDT) continue to persist in the environment as persistent organic pollutants. Although the EPA is working to decrease levels, environmental toxins remain a serious problem.

Why Order the Environmental Toxins Test?

Toxin exposures have been associated with several medical conditions and diseases. Individual risk varies based on the quantity of toxicant exposure, exposure time, genetic susceptibility, synergistic effects with other toxicants, and factors that influence detoxification pathways. Common areas of concern include cancer, cardiovascular disease, neurological disorders, immune dysfunction, developmental disorders, negative reproductive effects, hormonal imbalances, and a host of relevant symptoms and negative health outcomes. It is believed that most people are dealing with a toxic burden at some level—it’s just a matter of how much that toxic burden is contributing to somebody’s current symptoms or disease state. Understanding the potential risks associated with environmental toxins allows individuals to be proactive with their health. Here are the basic steps to reduce toxin burden.

Conditions, signs, and risks associated with environmental toxicity include:

Fatigue and weakness Heightened sensitivity to chemicals and foods Neurological dysfunction Depression and/or anxiety Loss of balance Dizziness Mood swings Slower reaction time Poor memory, difficulty finding words Difficulty concentrating Unusual skin sensations, tingling, and numbness Vision changes Headache, light sensitivity Hearing loss Irregular heartbeat Abdominal pain, diarrhea, and/or bloating Gastrointestinal dysfunction Mucosal irritation Chronic burning in the throat and nasal passages Tearing, disorientation, metallic taste in mouth Coughing, wheezing, and shortness of breath Eye irritation Endocrine imbalances Increased urinary frequency or increased thirst Autoimmune disease Morning stiffness and/or joint pain Muscle weakness Skin rashes Reproductive dysfunction Sleep problems Cancer

Environmental Toxins Markers:

Environmental Phenols: 4-Nonylphenol Bisphenol A (BPA) Triclosan (TCS)

Herbicides: 2,4-Dichlorophenoxyacetic Acid (2,4-D) Atrazine Atrazine mercapturate Glyphosate

Other Markers: Aryl Phosphate Diphenyl Phosphate (DPP) Acrylamide N-acetyl-S-(2-carbamoylethyl)- cysteine (NAE) Perchlorate (PERC)

Mitochondrial Marker: Tiglylglycine (TG)

Parabens: Butylparaben Ethylparaben Methylparaben Propylparaben

Pesticides: Diethyl phosphate (DEP) Dimethyl phosphate (DMP) Pyrethroid Pesticide Diethyldithiophosphate (DEDTP) Dimethyldithiophosphate (DMDTP) 3-Phenoxybenzoic Acid (3PBA) Diethylthiophosphate (DETP) Dimethylthiophosphate (DMTP) 2,2-bis(4-Chlorophenyl) acetic acid (DDA)

Phthalates: Mono-ethyl phthalate (MEP) mono-2-ethylhexyl phthalate (MEHP) mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) mono-(2-ethyl-5- hydroxyhexyl) phthalate (MEHHP)

Volatile Organic Compounds: Xylene Benzene 1,3-Butadiene 2-Methylhippuric Acid (2MHA) N-acetyl phenyl cysteine (NAP) N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NADB) 3-Methylhippuric Acid (3MHA) 1-Bromopropane Acrylonitrile 4-Methylhippuric Acid (4MHA) N-Acetyl (Propyl) Cysteine (NAPR) N-Acetyl (2-Cyanoethyl) Cysteine (NACE) Styrene Propylene Oxide Acrylonitrile, Ethylene Oxide Phenyl glyoxylic Acid (PGO) N-Acetyl (2,Hydroxypropyl) Cysteine (NAHP) 2-Hydroxyethyl Mercapturic Acid (HEMA) Methyl-tertiary-butyl ether (MTBE) 2-Hydroxyisobutyric Acid (2HIB)

What is the Heavy Metals Test?

Vibrant’s Heavy Metals test is a blood and/or urine test that measures levels of 20 heavy metals present in the blood or excreted in the urine, respectively.

Why Order Heavy Metals?

Heavy metal toxicity is under-represented as a root cause of illness and disease in humans. It is thought to affect over 1 million individuals annually and can affect virtually all biological systems in the human body. Heavy metals may be the root cause of common neurological disorders, gastrointestinal disorders, autoimmune diseases, and disorders associated with increased oxidative stress, and cellular dysfunction.

Conditions, signs, and risks associated with heavy metal toxicity:

Neurological symptoms: cognitive decline, memory loss, ataxia, tremors, numbness, tingling, neuropathy, myopathy, Alzheimer’s disease, multiple sclerosis, paralysis, Parkinson’s disease, tinnitus, irritability Respiratory symptoms: lung disease, lung cancer, breathing problems, respiratory distress, pneumonia Cardiovascular and hematological symptoms: anemia, RBC abnormalities, hypertension, low blood pressure, hypokalemia, edema, cancers of the blood Gastrointestinal symptoms: nausea, vomiting, diarrhea, abdominal pain, reduced absorption of nutrients (particularly minerals), dry mouth, metallic taste, pancreatic cancer Skeletal and bone-related symptoms: osteoporosis, reduced bone mineral density Dermatological symptoms: dermatitis, eczema, dry skin, sweating, skin lesions, hyperpigmentation, hair loss, allergic skin reactions Renal and hepatic symptoms: renal failure, elevated liver enzymes, hepatic damage, hepatic failure, suppressed hepatic detoxification, elevated hepatic enzymes Reproductive symptoms: infertility, difficulty conceiving, birth defects, miscarriage

What Markers Are Included?

Vibrant’s Heavy Metals test includes 20 heavy metals: Aluminum Antimony Arsenic Barium Beryllium Bismuth Cadmium Cesium Gadolinium Lead Mercury Nickel Palladium Platinum Tellurium Thallium Thorium Tin Tungsten Uranium

What is The PFAS Test?

Vibrant’s PFAS chemicals panel is a urine-based test that measures the levels of 21 different PFAS chemicals present in the urine. This test can be ordered as a stand-alone test or as part of the total toxin bundle to determine an individual’s exposure to PFAS chemicals.

What are PFAS?

The PFAS term encompasses thousands of per-and polyfluoroalkyl chemicals which are industrially produced for surface tension lowering or “non-stick” properties. PFAS offer water, oil, and stain-repellent capabilities and other friction-reduction benefits. PFAS are broadly used in aviation, automotive, and electronics industries, as well as in consumer goods such as cosmetics, paints, fast food packaging, carpets, floor polishes, herbicides, cookware, outdoor gear, and firefighting agents. Due to widespread applications, humans are often chronically exposed to PFAS daily. PFAS chemicals have a unique physicochemical structure. All PFAS chemicals contain a chain of carbon atoms chemically bonded to fluorine atoms. The carbon-fluorine bond is one of the strongest chemical bonds known and is difficult to break. As a result of this chemical property, PFAS can remain in the environment, humans, and wildlife for a very long time and therefore have become known as the “forever chemicals.

Conditions and symptoms which may benefit from PFAS testing include:

ADHD Allergies Asthma Autism spectrum disorder Cancer Cognitive decline Depression Diabetes Dyslipidemia Gastrointestinal dysfunction Gestational diabetes Hormone imbalances Hyperlipidemia Hypertension Immune dysfunction Infertility Inflammatory conditions Intestinal permeability Kidney disease Liver disease Low infant birth weight Memory impairments Neurological dysfunction Obesity Osteoporosis Pre-eclampsia Thyroid disease Ulcerative colitis

PFAS Test Markers:

GenX/HPFO-DA Dodecafluoro-3H-4,8- dioxanoate (NaDONA) Perfluoro-1-[1,2,3,4-13C4] octanesulfonic acid Perfluoro-n-[1,2-13C2] decanoic acid (MPFDA) Perfluorobutanoic acid (PFBA) Perfluorododecanoic acid (PFDoA) Perfluorohexane Sulfonic Acid (PFHxS) Perfluorononanoic acid (PFNA) Perfluorooctanoic acid (PFOA) Perfluorotetradecanoic acid (PFTeDA) Perfluoroundecanoic acid (PFUnA) 9-chlorohexadecauoro-3- oxanonane-1- sulfonate Perfluoro-[1,2-13C2] octanoic acid (M2PFOA) Perfluoro-1-heptane sulfonic acid (PFHpS) Perfluoro-n-[1,2-13C2] hexanoic acid Perfluorodecanoic acid (PFDeA) Perfluoroheptanoic acid (PFHpA) Perfluorohexanoic acid (PFHxA) Perfluorooctane sulfonic acid (PFOS) Perfluoropentanoic acid (PFPeA) Perfluorotridecanoic acid (PFTrDA)

Conditions Associated with Oxidative Damage:

An imbalance between the generation and buildup of ROS within cells and tissues, and the ability of innate biological systems and dietary antioxidants to eliminate these reactive byproducts, is linked to a wide range of conditions and chronic diseases, including: Cancer Cardiovascular disease Neurological conditions such as Alzheimer's Respiratory disease Rheumatoid arthritis Kidney disease Moreover, oxidative stress can create a detrimental cycle where one condition exacerbates another, leading to further health complications. By understanding an individual's oxidative stress, you can tailor treatment strategies to address potential weaknesses in the oxidative stress system, reduce buildup of ROS, and promote better health outcomes.

Oxidative Damage Markers:

Lipid Peroxidation Malondialdehyde Glutathione 4- hydroxynonenal (GS-HNE) 8-iso-prostaglandin F2α (8-iso-PGF2α) 11-β-Prostaglandin F2α 15(R)-Prostaglandin F2α DNA Damage 8-Hydroxy-2- deoxyguanosine (8-OHdG) 8-Hydroxyguanine 8- Hydroxyguanosine Protein Oxidation Dityrosine 3-Bromotyrosine 3-Chlorotyrosine Nitrative Stress Biomarkers 8-Nitroguanosine 8-Nitroguanine Nitrotyrosine Advanced Glycation Products Nε-(carboxymethyl) lysine (CML) Nε-carboxyethyllysine (CEL)

What is The Oxidative Stress Profile?

Oxidative Damage Markers + Antioxidant Genetics The Vibrant Oxidative Stress Profile measures 16 markers of cumulative oxidative damage eliminated from the body in the urine, plus 32 genetic variants that code for enzymes and antioxidants that can significantly impact oxidative stress response. This profile measures more analytes than any other test on the market, providing robust insight into oxidative damage to DNA, RNA, lipids, and proteins.

What Is Oxidative Stress?

Oxidative stress is when the body is unable to keep up with the accumulation of ROS due to poorly functioning endogenous antioxidants, inadequate intake of exogenous antioxidants, and/or diet and lifestyle that generates excess ROS. It’s possible to be genetically predisposed to excessive oxidative stress but protected by a nutrient-dense diet. Conversely, it’s possible to have fully functional endogenous antioxidants while being exposed to too many pro-oxidants from toxins, diet, and lifestyle for the body to keep up.

Why Order the Oxidative Stress Profile?

The Vibrant Oxidative Stress Profile offers a comprehensive evaluation of oxidative stress by assessing a broad range of markers that indicate damage caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) to lipids, DNA, RNA, and proteins. This detailed assessment provides valuable insights into the extent of oxidative damage, enabling tailored interventions for patients to mitigate oxidative stress-related health risks.

Insights With the inclusion of the Antioxidant Genetics panel, the test provides personalized insights into the genetic predispositions that influence an individual's antioxidant enzyme activity and overall oxidative stress response. Identifying risk-associated genetic variations can help you tailor interventions to enhance antioxidant defense mechanisms, optimize treatment strategies, and promote better health outcomes for your patients.

The Vibrant Oxidative Stress Profile report presents actionable information in a user-friendly format, including summary flowcharts, graphical representations of oxidative damage scores, and color-coded indicators for risk levels. This facilitates informed decision-making, allowing you to prioritize interventions based on areas of concern, track improvements over time, and empower patients to make proactive lifestyle and dietary choices to promote overall health and well-being.

Oxidative Stress Profile Markers:

SNP ID & Gene: rs2796498 PRKAA2 rs10789038 PRKAA2 rs1001179 CAT rs7943316 CAT rs4756146 CAT rs20417 COX-2 rs916321 CYB5R3 rs1048943 CYP1A1 rs10911021 GLUL rs1050450 GPX1 rs1987628 GPX1 rs4902346 GPX2 rs2071566 GPX2 rs713041 GPX4 rs366631 GSTM1 rs3754446 GSTM5 rs1695 GSTP1 rs121909307 GSS rs8190955 GSR rs2071746 HMOX1 rs4673 CYBA rs9932581 CYBA rs3877899 SELENOP rs2234694 SOD1 rs4880 SOD2 rs1799895 SOD3 rs8192287 SOD3 rs7310505 TXNRD1 rs1548357 TXNRD2 rs4485648 TRXR2 rs206812 XDH rs2073316 XDH

Other Markers:

Lipid Peroxidation: Malondialdehyde Glutathione 4- hydroxynonenal (GS-HNE) 8-iso-prostaglandin F2α (8-iso-PGF2α) 11-β-Prostaglandin F2α 15(R)-Prostaglandin F2α

DNA Damage: 8-Hydroxy-2- deoxyguanosine (8-OHdG) 8-Hydroxyguanine 8- Hydroxyguanosine

Protein Oxidation: Dityrosine 3-Bromotyrosine 3-Chlorotyrosine Nitrative Stress Biomarkers 8-Nitroguanosine 8-Nitroguanine Nitrotyrosine

Advanced Glycation Products: Nε-(carboxymethyl) lysine (CML) Nε-carboxyethyllysine (CEL)

The Vibrant Wellness Advantage

A robust range of markers, including inhibitory and excitatory neurotransmitters, neuromodulators, amino acids and metabolites Inhibitory and excitatory neurotransmitters and neuromodulators Simple testing with robust results. Perform the Neurotransmitters panel in the comfort of your home. Unparalleled specificity and sensitivity. Our proprietary technology detects: Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

What is The Neurotransmitters Test?

Vibrant’s Neurotransmitter Test is a urine-based test that measures levels of the most common neurotransmitters and metabolites in the brain and nervous system. It includes inhibitory, excitatory, and other neurotransmitters along with diurnal rhythm of epinephrine and norepinephrine, providing insight into how the nervous system is communicating.

Why Order The Neurotransmitters Test?

The neurotransmitter test is a non-invasive test that provides a snapshot of an individual’s specific neurotransmitter levels. This test provides insight into how the nervous system is communicating. Many treatment recommendations used with neurological or mental conditions are currently guided by a general diagnosis or a "trial and error" approach. The neurotransmitter test can provide clinically useful data to help guide you when monitoring and treating neurological or mental health conditions. It can also be used to assess medication efficacy and responsiveness or help wean medications or supplements. Neurotransmitter imbalances can be caused by a host of factors. The neurotransmitter test allows you to assess all aspects of neurotransmitter synthesis and metabolism, highlighting where issues occur on the neurotransmitter pathways so interventions can be tailor-made.

Which Patients Benefit from This Test?

ADHD/ADD Addictive behaviors Alzheimer’s disease Altered pain response Anger Anxiety Appetite (poor/excess) Autism spectrum disorder Autoimmune diseases Autonomic nervous system disorders Bipolar disorder Brain fog Cancer Cardiovascular disease Chronic fatigue Constipation/ diarrhea Compulsive behaviors Dementia Depression Developmental disorders Difficulty concentrating Diabetes Dysmotility Eating disorders Epilepsy/seizure disorders Fatigue Fibromyalgia Gastroesophageal reflux disease Headaches/migraines Hormonal Imbalances Hyperactivity Huntington’s disease Irritable bowel syndrome (IBS) Insomnia Irritable bowel disease (IBD) Irritability Low libido Low motivation Medication adjustments Memory impairments Mood disorders Movement disorders/ Motor dysfunction Multiple sclerosis Muscle twitching/spasms Obsessive compulsive disorder Panic attacks Parkinson’s disease Schizophrenia Sensory processing disorders Tremors Weight imbalances Vomiting

Neurotransmitters Test Key Markers:

Excitatory Neurotransmitters: Glutamate Histamine PEA Dopamine DOPAC HVA Norepinephrine Epinephrine VMA Acetylcholine Aspartate Oxytocin

Inhibitory Neurotransmitters: Serotonin 5-HIAA GABA Glycine Taurine

Other Neurotransmitters: 3-Methoxytyramine Metanephrine Tryptamine Tyrosine Tyramine Serine 5-HTP L-DOPA Xanthurenic acid Quinolinic acid Kynurenic acid

Ratios: Norepinephrine /Epinephrine HVA/VMA HVA/DOPAC Quinolinic acid/5-HIAA

Diurnal Epinephrine: Epinephrine (1st Morning) Epinephrine (2nd Morning) Epinephrine (Evening) Epinephrine (Night)

Diurnal Norepinephrine: Norepinephrine (1st Morning) Norepinephrine (2nd Morning) Norepinephrine (Evening) Norepinephrine (Night)

The Vibrant Wellness Advantage

Simple testing with robust results. Peptide-level antibody detection of 48 of the most well-studied brain and nervous system antibodies. Unparalleled sensitivity and specificity. Our proprietary technology uses a fully automated multiplex platform to achieve highly specific and sensitive results at 94-100% accuracy. Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

What is the Neural Zoomer Plus?

The Neural Zoomer Plus analyzes an array of neurological protein antigens associated with neural tissues, receptors, and cells, as well as various viral and bacterial antigens linked to acute and chronic nervous system infections. The test measures the immune system's antibody response to these antigens, which can lead to brain damage and contribute to neurological inflammation, infection, and autoimmune disorders.

Why is This Test Important?

Neural Zoomer Plus measures immune reactivity to structures, tissues, cells, and chemicals in the brain and peripheral nervous system. This test enables you and your care provider to pinpoint the mechanisms behind disease progression and develop a personal roadmap to improved neurological health.

Which Patients Will Benefit from This Test?

Ataxia/balance problems Sensory loss Neuropathic pain Optical decline Photosensitivity Muscle pain/spasms Muscle weakness/atrophy Orthostatic hypertension Chronic pain or fibromyalgia Memory loss or brain fog Autoimmune disease Attention deficit/ADHD Traumatic brain injury/history of concussion Cognitive decline Alzheimer’s disease Multiple sclerosis or demyelinating diseases Encephalitis Huntington’s disease Epilepsy Parkinson’s disease Dementia Myasthenia gravis Muscle stiffness/rigidity Neuromyelitis optica Autism PANDAS/PANS/OCD

Neural Zoomer Plus Markers:

Demyelination Antigens: Anti-MAG Anti-Neurofascin Anti-Myelin oligodendrocyte glycoprotein Anti-Myelin basic Protein Anti-Myelin proteolipid protein Anti-Tubulin

Brain Autoimmunity: Anti-Cerebellum Anti-Purkinje cell Anti-Yo Anti-Amyloid beta (1-42) Anti-Tau Anti-Glutamate Anti-Dopamine Hydroxytryptamine Anti-Alpha-synuclein Anti-alpha1 and beta2 adrenergic receptors Anti-Endothelin A receptor Anti-Amyloid beta (25-35) Anti-RAGE peptide

Blood Brain Barrier Disruption: Anti-Microglia Anti-Glial fibrillary acidic protein Anti-s100b Ant-Glucose regulated protein 78

Optical and Autonomic Nervous System Disorders: Anti-Neuron specific enolase Anti-Aquaporin4 Anti-Recoverin Anti-CVX

Peripheral Neuropathy: Anti-GM1 Anti-Gm2 Anti-Hu Anti-Ri Anti-Amphiphysin

Neuromuscular Disorders: Anti-Muscle specific kinase Anti-Voltage gated calcium channels Anti-Voltage gated potassium channels Anti-Titin Anti-Acetylcholine receptors

Brain Inflammation: Anti-NMDA receptor Anti-AMPA receptor Anti-Dopamine receptor 1 Anti-Dopamine receptor 2 Anti-GABA receptors Anti-Dipeptidyl aminopeptidase like protein 6 Anti-Glycine receptor Anti-Neurexin 3 Anti-Contactin associated protein-like 2 Anti-Leucine-rich glioma-inactivated protein 1 (AntiLGI1) Anti-Ma

Infections: Anti-HSV1 Anti-HSV2 Anti-EBV Anti-CMV Anti-HHV 6 Anti-HHV 7 Anti-Streptococcal A

What Are Food Zoomers?

Vibrant's Food Zoomers are blood tests that use IgA and IgG antibodies to measure immune system reactivity to small, 2-dimensional peptides formed when whole proteins are broken down by digestion.

In contrast, the Food Sensitivity Test measures immune system reactivity to whole, undigested, multi-dimensional proteins using IgA and IgG antibodies.

Wheat, Peanut, and Tree Nut Zoomers are on separate Key Clinical Messages given the unique immunogenic, immunotoxic, and allergenic profiles of wheat, peanut, and tree nuts.

Vibrant’s Food Zoomer test menu includes: Corn Zoomer Dairy Zoomer Egg Zoomer Grain Zoomer Lectin Zoomer Soy Zoomer.

Corn Zoomer

Who Will Benefit from the Corn Zoomer test? The Corn Zoomer panel detects the body’s reaction to antigens in both conventional and GMO (genetically modified) corn. People with wheat and gluten sensitivity are more likely to have corn sensitivity despite corn being gluten-free. If you are diagnosed with or suspect Celiac disease or wheat sensitivity, food sensitivities or allergies, or intestinal permeability, you may benefit from this panel.

Recognizing Symptoms of Corn Sensitivity Symptoms include: Bronchitis and asthma symptoms Rashes (eczema) Arthritis Gas Bloating Fever Fatigue Diarrhea Abdominal pain Known intestinal hyper permeability (such as on the Vibrant Wheat Zoomer) Nausea and vomiting Skin itchiness and redness Joint pain Muscle stiffness and swelling Weakness

Dairy Zoomer:

Who Will Benefit from the Dairy Zoomer test? The Dairy Zoomer panel detects the body’s reaction to dairy or cow’s milk. Dairy sensitivity includes the delayed, mild to moderate symptoms associated with the consumption of cow’s milk and associated products.

If you are diagnosed with or suspect food sensitivities or allergies, intestinal permeability, type 1 diabetes, autoimmune disease (multiple sclerosis and uveitis), autism, or have a family history of dairy sensitivity or allergy, you may benefit from this panel.

Recognizing Symptoms of Dairy Sensitivity: Abdominal pain during or after meals Gas Bloating Colic (Infants) Eczema or other rashes Mucous-filled cough Runny nose Eye irritation Recurring ear infections Other food sensitivities and allergies Atopic dermatitis

Egg Zoomer:

Who Will Benefit from the Egg Zoomer test? The Egg Zoomer panel detects the body’s reaction to eggs, including egg white and egg yolk allergy and sensitivity. If you suspect or are diagnosed with food sensitivities or allergies, intestinal permeability, or have a family history of egg sensitivity or allergy, you may benefit from this panel.

Recognizing Symptoms of Egg Sensitivity Excessive gas Bloating Stomach pain and cramps Vomiting Difficulty breathing Headaches Skin reactions Joint pain Heartburn Irritability Nervousness Nausea

Grain Zoomer:

Who Will Benefit from the Grain Zoomer test? The Grain Zoomer panel detects the body’s reaction to commonly consumed grains. If you are diagnosed with or suspect food sensitivities, allergies, or intestinal permeability, you may benefit from this panel.

Recognizing Symptoms of Grain Sensitivity: Rashes (eczema) Arthritis Gas Bloating Fever Fatigue Diarrhea Abdominal pain Nausea and vomiting Skin itchiness and redness Bronchitis and asthma symptoms Muscle stiffness and swelling Sweating and feeling weak

Lectin Zoomer:

Who Will Benefit from the Lectin Zoomer test? The Lectin Zoomer panel detects the body’s reaction to lectins. Lectins are sugar-binding proteins that occur naturally in all organisms, but lectins found in common foods like grains, legumes, and nightshades (tomatoes, peppers, eggplants, etc.) can cause microbial imbalances, damage the gut lining, and provoke the immune system in those with sensitivities. If you are diagnosed with or suspect food sensitivities, allergies, intestinal permeability, or have a history of rheumatoid arthritis or neural autoimmunity, you may benefit from this panel.

Recognizing Symptoms of Lectin Sensitivity: Fatigue and tiredness Psychological symptoms or disorders (ex: depression) Neurological autoimmunity or degenerative symptoms of undefined origin Skin rashes Nausea (especially during or after meals) Diarrhea Joint pains Lack of concentration/brain fog Fluctuating weight

Nut Zoomer:

Who Will Benefit from the Nut Zoomer test? The Nut Zoomer test detects sensitization and immune reactivity to tree nuts. If you are diagnosed with or suspect food sensitivities or allergies or have a family history of allergies or sensitivities to tree nuts or peanuts, you may benefit from this panel.

Recognizing Symptoms of Tree Nut Sensitivity: Abdominal pain and cramps Bloating Migraines Headaches Cough Diarrhea Nasal congestion or a runny nose Nausea Irritable bowel Hives

Peanut Zoomer:

Who Will Benefit from the Peanut Zoomer test? The Peanut Zoomer can detect the prevalence of a peanut allergy and a peanut sensitivity. You may benefit from this panel if you have known food sensitivities or food allergies or a family history of peanut allergies.

Recognizing Symptoms of a Peanut Sensitivity Fatigue (sluggish/tired) Stomach pains/cramps Nausea Headaches Migraines Rashes or hives Hyperactivity (nervous energy) Diarrhea Wheezing Symptoms resembling IBS Increased irritability, hyperactivity, and repetitive behaviors in children with autism Presence of other food sensitivities and allergies Skin problems (eczema) Asthma Joint pains Brain fog Problems with mood or memory Digestive distress

Soy Zoomer:

Who Will Benefit from the Soy Zoomer test? The Soy Zoomer panel detects the body’s reaction to conventional and genetically modified soy. If you are diagnosed with or suspect food sensitivities, food allergies, or intestinal permeability, you may benefit from the Soy Zoomer. Due to the high cross-reactivity between soy and peanuts, you may also benefit from this panel if you have or suspect you have peanut allergies or sensitivities.

Recognizing Symptoms of Soy Sensitivity: Atopic dermatitis Eczema Diarrhea Excessive gas or bloating Asthma-like symptoms Wheezing Difficulty breathing Runny nose or watery eyes

Wheat Zoomer:

The Wheat Zoomer can be utilized for the detection of celiac disease, non-celiac gluten sensitivity, wheat lectin sensitivity, non-gluten wheat sensitivity, increased intestinal permeability, intestinal damage associated with celiac disease, and gluten-related autoimmunity. The Wheat Zoomer can also be utilized for people already following a gluten-free or wheat free diet to gain insight on diet compliance and/or to help identify accidental exposure. Research suggests that a single exposure from gluten can elevate antibodies anywhere from 2-6 months in a person (varies individually). Therefore, the Wheat Zoomer can be used to track gluten exposure over time. The Celiac Disease Foundation recommends testing annually for celiac disease, even after a celiac disease diagnosis, as a way of monitoring disease activity and dietary compliance.

What types of patients are good candidates for Wheat Zoomer testing? Suspected Gluten or Wheat Sensitivity Suspected Intestinal Permeability (Leaky Gut Syndrome) Gastrointestinal inflammation (diarrhea or constipation; cramping; nausea; discomfort after eating) Headaches, including migraines Neurological symptoms (memory loss, balance problems, numbness, tingling, anxiety) Skin rashes Joint pain Diagnoses of autoimmune conditions Low Vitamin D status Multiple Food Sensitivities Excessive fatigue after meals

What is The Toxin Genetics Test?

The Toxin Genetics Test assesses for multiple genetic variations that affect detoxification. This test is available as a stand-alone test by sampling either saliva or blood to determine an individual’s risk for impaired detoxification.

Who Will Benefit from Toxin Genetics Testing?

The Toxin Genetics Test uses single nucleotide polymorphisms (SNPs) to assess genetic predisposition for defective detoxing. There are numerous factors that can cause impaired detoxing, including toxic burden, medications, nutrition, and genetics. Certain SNPs can affect the function of detox enzymes as well as how dietary factors interact with those enzymes. Additionally, toxins can lead to elevated oxidative stress and increase demand on the body’s detoxification pathways, particularly in the liver. When the liver can’t adequately eliminate toxins or infectious byproducts, these toxins can clog up normal detox pathways, and lead to a range of chronic inflammation symptoms. If you’re experiencing multiple chronic symptoms and can’t lose weight despite diet and exercise, you may be detoxing inefficiently and/or carrying a high toxic burden.

Defective Detoxing/High Toxic Burden Symptoms include:

Heightened sensitivity to chemicals in foods Disorientation Metallic taste in the mouth Irregular heartbeat Morning stiffness or joint pain Mood swings Muscle weakness Skin rashes Sleep problems Vision or hearing changes Poor memory, difficulty finding words Difficulty concentrating Unusual skin sensations, tingling, and numbness Increased urinary frequency or thirst Abdominal pain, diarrhea, or bloating Static shocks Fatigue and weakness Chronic burning in the throat and nasal passages Coughing, wheezing, shortness of breath Balance loss or dizziness Depression or anxiety Eye irritation or tearing Headache and light sensitivity.

Toxin Genetics Test Markers:

Environmental Toxins: rs2234922 EPHX1 Benzene rs1051741 EPHX1 Benzene rs751141 EPHX2 Benzene rs1902023 UGT2B15 Bisphenol A, Parabens (MeT, EtP) rs1048943 CYP1A1 Organochlorine, Organophosphate rs1056836 CYP1B1 Pesticides (Diazinon, Malathion) rs1695 GSTP1 Benzidine, styrene, pesticides rs1138272 GSTP1 Tobacco smoke, alcohol

Mycotoxins: rs2228001 XPC Aflatoxin rs11076161 MT1A rs2056131 ITGB3 Increased Mold sensitivity rs13181 XPD Aflatoxin rs28383151 XRCC4 Aflatoxin rs3734091 XRCC4 Aflatoxin rs25487 XRCC1 Aflatoxin rs861539 XRCC3 Aflatoxin rs7003908 XRCC7 Aflatoxin

Heavy Metals: rs11076161 MT1A Cadmium rs1695 GSTP1 Arsenic, cadmium, mercury rs1138272 GSTP1 Mercury rs713041 GPx4 Mercury rs1050450 GPx1 Methylmercury, lead, tobacco

Xenobiotics: rs1042157 SULT1A1 Poor xenobiotic detoxification rs762551 CYP1A2 Poor xenobiotic detoxification rs1871042 GSTP1 Poor xenobiotic detoxification rs713041 GPx4 Poor xenobiotic detoxification

PFAS: rs1048943 CYP1A1 PFOS, PFOA rs1056836 CYP1B1 PFAS

The Vibrant Wellness Advantage

Steroid hormones and topical hormones Saliva cortisol and saliva cortisone Simple testing with robust results. Perform the Salivary Hormones panel in the comfort of your home. Unparalleled specificity and sensitivity. Our proprietary technology detects: Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

What is the Salivary Hormones Test?

The Salivary Hormones Test is a panel of 18 hormone analytes that measure diurnal sex steroid and glucocorticoid hormone output. The samples are collected at home, in saliva, four times daily. Salivary hormone testing measures bioavailable hormone production rather than protein-bound hormone production, which is typically measured in serum.

Who Will Benefit from the Salivary Hormones Test?

The Salivary Hormones test measures levels of important reproductive and metabolic hormones in the body that relate to energy, weight fluctuations, water retention, muscle loss or gain, sleep, mood, and cognitive function. The primary benefit of salivary testing is that steroid hormones collected from saliva are unconjugated and/or bioavailable rather than the total, or protein bound hormones which are typically measured in serum. Hormones are essential chemical messengers which regulate routine processes in the body. This test is helpful in the evaluation of sex steroid imbalance such as deficiency or excess of estrogen, progesterone, or testosterone/DHEAS-S. This panel also helps to assess adrenal function and conditions relating to excess or deficiency of cortisol, as well as HPA axis imbalance. Adrenal function testing can also offer insight into neurotransmitter levels and mood disorders.

Recognizing Symptoms of Hormonal Imbalances

Hot flashes Night sweats Headaches Hair loss Poor sleep Anxiety Depression Stress Low libido Memory lapse Sugar cravings Weight gain Dry, dull appearance of skin Symptoms include: Poor stamina Decreased muscle mass/strength Neck/back pain Decreased urinary flow (men) Thinning hair, eyebrows, or eyelashes Erectile dysfunction Apathy/mood changes Poor cognition Brain fog Fatigue Chronic Irritability Increased facial hair/acne Irregular menstrual cycles

Salivary Hormones Key Markers:

Saliva Steroids Hormones: Estradiol (E2) Estrone (E1) Estriol (E3) E3/(E1+E2) Ratio Progesterone (Pg) Pg/E2 Ratio Testosterone DHEA-S

Saliva Cortisol: Cortisol (Pooled) Cortisol (Morning) Cortisol (Noon) Cortisol (Evening) Cortisol (Night)

Saliva Cortisone: Cortisone (Pooled) Cortisone (Morning) Cortisone (Noon) Cortisone (Evening) Cortisone (Night)

The Vibrant Wellness Advantage

Steroid hormones and downstream metabolites Four-point diurnal free cortisol, free cortisone, and melatonin Simple testing with robust results. Perform the Urinary Hormones Panel in the comfort of your home. Unparalleled specificity and sensitivity. Our proprietary technology detects: Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

What is the Urinary Hormone Test?

The Urinary Hormone Test is our most comprehensive hormone test panel. It measures 67 analytes in four collections from day to night. The analytes include sex steroids, glucocorticoid hormones, hormone metabolites, melatonin, bisphenol A (BPA), and 8-hydroxydeoxyguanosine (8-OHdG). Evaluation of steroid output, in addition to metabolism pathways, can provide meaningful insight into enzymatic regulation, Phase I and II detoxification, and other systemic functions. These analytes can provide meaningful insight into enzymatic regulation, Phase I and II detoxification, and other systemic functions. The Urinary Hormone Test provides a powerful tool for providers to understand a patient’s physical presentation and develop more effective intervention plans.

Who Will Benefit From the Urinary Hormones Panel?

The Urinary Hormones Panel measures the status of steroid hormones in the human body, including patterns of imbalances and an assessment of metabolites (metabolized hormones). Hormones are essential chemical messengers which regulate routine processes in the body. If you were diagnosed with or suspect a mood disorder, neurotransmitter imbalance, or hormonal imbalance, you may benefit from this panel.

Additional issues the Urinary Hormone Test can benefit:

Patients with estrogenic cancer risk Insomnia Patients with circadian rhythm imbalances Patients currently taking melatonin supplementation Patients with high risk for oxidative damage (CVD, cancer, excess pollutant exposure, smokers)

Recognizing Symptoms of Hormonal Imbalances:

Hot flashes Night sweats Headaches Hair loss Poor sleep Anxiety Depression Stress Low libido Memory lapse Sugar cravings Weight gain Dry, dull appearance of skin Symptoms include: Poor stamina Decreased muscle mass/strength Neck/back pain Decreased urinary flow (men) Thinning hair, eyebrows, or eyelashes Erectile dysfunction Apathy/mood changes Poor cognition Brain fog Fatigue Chronic Irritability Increased facial hair/acne Irregular menstrual cycles Rapid aging

Urinary Hormones Panel Markers:

URINARY ESTROGENS (G/G CR): Estradiol (E2) Estrone (E1) Estriol (E3) E3/(E1+E2) Ratio 2-OH Estradiol 2-OH Estrone 4-OH Estradiol 4-OH Estrone 16a-OH Estrone 2-OH (E1 + E2)/16a-OH E1 2-MeO Estradiol 2-MeO Estrone 2-MeO E1/2-OH E1 4-MeO Estradiol 4-MeO Estrone 4-MeO E1/4-OH E1 4-MeO E2/4-OH E2 Bisphenol A Total Estrogen

URINARY ANDROGENS (G/G CR): DHEA Androstenedione Androsterone Etiocholanolone Testosterone (T) Epi-Testosterone (Epi-T) T/Epi-T 5a-DHT DHEA-S 5a,3a-Androstanediol 5b-Androstanediol

URINARY PROGESTOGENS (G/G CR): b-Pregnanediol a-Pregnanediol Allopregnanolone Allopregnanediol 3αDihydroprogesterone 20αDihydroprogesterone b-Pregnanediol/E2

URINARY GLUCOCORTICOIDS: Total Cortisol Total Cortisone Cortisol/Cortisone b-Tetrahydrocortisol (b-THF) a-Tetrahydrocortisol (a-THF) b-Tetrahydrocortisone (b-THE) Metabolized Cortisol (THF+THE) Deoxycorticosterone Corticosterone

OXIDATIVE STRESS: 8-OHdG

What is the MTHFR Test?

Vibrant’s MTHFR Test is a genetic test that assesses for two polymorphisms, C677T and A1298C. You can order this test as a stand-alone test by sampling either saliva or blood to determine an individual's risk for hyperhomocysteinemia, methylation impairments, and associated conditions.

What is MTHFR?

Methylenetetrahydrofolate reductase (MTHFR) is an essential regulatory enzyme in the folate cycle. MTHFR function can affect folate, homocysteine, and methionine metabolism and the synthesis of proteins, DNA, and RNA. It is responsible for converting 5,10-methylene-tetrahydrofolate to 5-methyltetrahydrofolate, which is the form used to convert homocysteine back to methionine for DNA methylation and maintenance of healthy vasculature.

Why Order the MTHFR Test?

Individuals with MTHFR genetic polymorphisms may be at increased risk for hyperhomocysteinemia, an independent risk factor for cardiovascular disease. Elevated levels of homocysteine are associated with numerous conditions², including: Cardiovascular disease Heart attack Stroke Peripheral artery disease Venous thrombosis Pregnancy complications And neural tube defects. MTHFR genetic polymorphisms can impair methionine metabolism, which may influence DNA methylation and gene expression. Methylation is generally associated with "switching off" or inhibiting a gene and can therefore have a broad range of impacts on the body. The benefit of understanding an individual's genetic risk factor is to enable lifestyle, dietary, and supplement plans tailored to address increased risk factors for disease.

Conditions and symptoms which may benefit from MTHFR testing include:

Hyperhomocysteinemia Cardiovascular disease History of heart attack or stroke (or family history) Peripheral artery disease Thrombosis History of pregnancy complications History of a child born with neural tube defects Developmental delays Psychological and mood disorders Parkinson’s disease Alzheimer's disease Inflammatory bowel disease Cancer Diabetes Neurological disorders Seizures Inflammatory conditions Those who seek to understand their genetic risk (everyone)

What Markers Are Included in the MTHFR genetic test?

C677T and A1298C

The Vibrant Wellness Advantage

Unparalleled specificity and sensitivity. Our proprietary technology detects: SNP (Single Nucleotide Polymorphism) mutations linked to chronic heart disease and associated conditions. Validated and accredited. Science-backed testing and analysis based on rigorous, ongoing research by clinical experts.

What is the CardiaX Test?

The Vibrant Wellness CardiaX test is a genetic microarray test which detects and interprets 21 different genetic variants associated with increased predisposition to heart conditions, as well as metabolic responses to cardiac medications. This test can be performed by collecting either saliva or blood.

Who Will Benefit from the CardiaX Testing?

The CardiaX panel by analysis assesses genetic predispositions associated with chronic heart diseases. If you were diagnosed with or suspect a family history of chronic heart disease, early onset heart disease, risk of atherosclerosis, chronic cerebral ischemia risk, or risk of heart attack, you may benefit from this panel.

Why is This Test Important?

Chronic heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. The Vibrant Wellness CardiaX panel will help you assess your genetic risk of chronic heart disease, chronic cerebral ischemia, and various related medical conditions. The panel includes markers for genes that are directly linked to cardiovascular conditions such as atherosclerosis, abnormal cholesterol production, hypertension, chronic cerebral ischemia, and even heart attack. This panel enables detection of genetic risk of chronic heart disease and associated conditions and can be utilized along with other cardiac testing to create a cardiac wellness plan based on your unique genetics.

Cardia X Test Markers:

9p21 Chronic heart disease, inflammation, plaque rupture, abdominal aortic aneurysm, atherosclerosis, chronic coronary disease

4q25 Atrial Fibrillation, chronic cerebral ischemia

1q25 Chronic heart disease

ApoE Chronic heart disease, cardiovascular disorder, chronic coronary disease, Alzheimer's disease, dementia

MTHFR Hypertension, chronic coronary disease, endothelial dysfunction, hyperhomocysteinemia

CYP1A2 Hypertension, chronic coronary disease, tachycardia, aortic stenosis

Corin Hypertension, congestive heart failure, cardiovascular disease, pre-eclampsia (pregnant women)

NOS3 Hypertension, chronic heart disease, chronic coronary disease

ADR-B2 Venous thrombosis, hypertension, chronic cerebral ischemia

AGTR1 Hypertension

What is the Factor II-V Test?

Vibrant’s Factor II-V Test is a genetic test that assesses for two genetic mutations, Factor II 20210 G>A and Factor V Leiden 1691 G>A. This test can be ordered as a stand-alone test by sampling either saliva or blood to determine an individual’s increased risk for blood clots.

Why Order the Factor II-V Test?

The Factor II-V genetic test can identify increased risk and inherited disorders of blood clothing. A factor II mutation occurs on the F2 gene, which is known as a prothrombin 20201 G>A mutation. A factor II mutation can result in increased levels of plasma prothrombin, called prothrombin thrombophilia, which may increase the risk of developing blood clots and developing them at a younger age.1 This occurs because the factor II gene produces a protein called prothrombin, the precursor to thrombin integral to the coagulation cascade. A factor V Leiden mutation occurs on the F5 gene, referred to as the factor V Leiden variant 1691 G>A. A factor V Leiden mutation is also associated with an increased risk for venous thromboembolism, leading to a condition called Factor V Leiden thrombophilia.

Factor II and factor V Leiden genetic mutations may increase the risk for thrombosis, which often manifests as deep-vein thrombosis in the legs or pulmonary embolism; however, they can also occur in the brain, eyes, liver, and kidneys. Those who are heterozygous for the 20210 G>A variant have a two fivefold increased relative risk for developing deep-vein thrombosis.² Individuals who are heterozygous for both Factor II 20210 G>A and Factor V Leiden variants have a seven to twenty-fold increased risk for venous thromboembolism.¹ Besides genetic risk, many other factors may increase the risk for blood clots, including contraceptive use, hormone replacement therapy, obesity, traveling, and more. Understanding an individual’s genetic risk factor is essential to provide the opportunity to tailor lifestyle, dietary, supplement, and medication interventions to address any increased risk factors for disease.

Which Patients Benefit from This Test?

Venous thromboembolism Deep vein thrombosis Pulmonary embolism Pregnancy complications, including thrombosis during pregnancy or due to estrogen-containing contraceptive use Idiopathic stroke in young individuals Family history of stroke Any individual seeking to understand their genetic risk

What Markers Are Included on the Factor II-V genetic test?

Factor II 20210 G>A Factor V Leiden 1691 G>A